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Tubulin inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (256) ADC Cytotoxin (40) ADC Linker (4) Akt (3) Amyloid-β (1) Antibiotic (1) Apoptosis (98) Autophagy (7) Bacterial (2) Bcr-Abl (2) Casein Kinase (1) Caspase (1) Cholinesterase (ChE) (2) Complement System (1) CRISPR/Cas9 (1) Drug-Linker Conjugates for ADC (64) EGFR (2) ERK (1) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (1) FLT3 (1) HDAC (20) HIF/HIF Prolyl-Hydroxylase (2) Histone Demethylase (1) Histone Methyltransferase (1) HPV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (4) JAK (1) MDM-2/p53 (2) Mitochondrial Metabolism (1) MMP (3) mTOR (1) NOD-like Receptor (NLR) (3) Parasite (5) PARP (2) PI3K (2) Polo-like Kinase (PLK) (1) Proton Pump (1) Reactive Oxygen Species (7) Sirtuin (4) Src (1) STAT (1) Tau Protein (2) TGF-beta/Smad (1) Topoisomerase (1) VEGFR (3) YAP (1)
By Research Areas:	Cancer (355) Cardiovascular Disease (2) Endocrinology (1) Infection (6) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (9)
Click Chemistry:	ADC Synthesis (1) TCO (1) DBCO (4) Azide (3)

392

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Microtubule/Tubulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152156

Tubulin inhibitor 11	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 11 is a potent and orally active *tubulin* inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis .

HY-149856

Tubulin inhibitor 33	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 33, a *tubulin* polymerization inhibitor, inhibits *tubulin* polymerization in a dose-dependent manner with an IC₅₀ of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research .

HY-146711

Tubulin inhibitor 24	Microtubule/Tubulin	Cancer
Tubulin inhibitor 24 is a potent *tubulin* inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity .

HY-145821

Tubulin inhibitor 15	Microtubule/Tubulin	Cancer
Tubulin inhibitor 15 is a potent *tubulin* inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells .

HY-145822

Tubulin inhibitor 16	Microtubule/Tubulin	Cancer
Tubulin inhibitor 16 is a potent *tubulin* inhibitor. Tubulin inhibitor 16 shows antiproliferative activity. Tubulin inhibitor 16 shows cytotoxicity in HepG2 cells .

HY-151996

Tubulin inhibitor 31	Microtubule/Tubulin	Cardiovascular Disease
Tubulin inhibitor 31 is a potent *tubulin* inhibitor with an IC₅₀ value of 4 µM. Tubulin inhibitor 31 shows anti-proliferative activity. Tubulin inhibitor 31 inhibits the HUVEC migration .

HY-115956

Tubulin inhibitor 18	Microtubule/Tubulin	Cancer
Tubulin inhibitor 18 (compound 5j) is a potent inhibitor of *tubulin. Tubulin* inhibitor 18 is a chalcone compound. Tubulin inhibitor 18 has the potential for the research of cancer diseases .

HY-136121

Tubulin inhibitor 6	Microtubule/Tubulin	Cancer
Tubulin inhibitor 6 (Compound 14b) is a *tubulin* inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC₅₀ of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC₅₀ of 840 nM .

HY-136123

Tubulin inhibitor 8	Microtubule/Tubulin	Cancer
Tubulin inhibitor 8 (Compound 33b) is a *tubulin* inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC₅₀ of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC₅₀ of 14 nM .

HY-136122

Tubulin inhibitor 7	Microtubule/Tubulin	Cancer
Tubulin inhibitor 7 (Compound 33c) is a *tubulin* inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC₅₀ of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC₅₀ of 11 nM .

HY-144818

Tubulin inhibitor 23	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 23 is a potent *Tubulin* inhibitor with an IC₅₀ of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia .

HY-115957

Tubulin inhibitor 19	Microtubule/Tubulin	Cancer
Tubulin inhibitor 19 (compound 9b) is a potent inhibitor of *tubulin. Tubulin* inhibitor 19 is an indole chalcone compound. Tubulin inhibitor 19 has the potential for the research of cancer diseases .

HY-163195

Tubulin inhibitor 40	Microtubule/Tubulin	Cancer
Tubulin inhibitor 40 (compound 45) is a *tubulin* inhibitor with IC₅₀ of 1.2 μM. Tubulin inhibitor 40 shows selective cytotoxicity towards cancer cells. Tubulin inhibitor 40 processes antitumor activity .

HY-115958

Tubulin inhibitor 20	Microtubule/Tubulin	Cancer
Tubulin inhibitor 20 (compound 1) is a potent inhibitor of *tubulin. Tubulin* inhibitor 20 has the potential for the research of cancer diseases .

HY-149252

Tubulin inhibitor 32	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 32 is a potent and orally active *tubulin* inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity .

HY-147888

Tubulin inhibitor 29	Microtubule/Tubulin	Cancer
Tubulin inhibitor 29 (compound 3c) is a potent *tubulin* inhibitor with an IC₅₀ value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC₅₀ value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site .

HY-151879

Tubulin inhibitor 30	Microtubule/Tubulin Ferroptosis	Cancer
Tubulin inhibitor 30 (Compound 15) is a *tubulin* assembly inhibitor with an IC₅₀ of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis .

HY-112607

Tubulin inhibitor 1	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 1 is a *tubulin* inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis .

HY-143251

Tubulin inhibitor 13	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 13 (E27) is a potent *tubulin* inhibitor with an IC₅₀ value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity .

HY-149364

Tubulin inhibitor 34	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 34 (compound b5) is a potent anticancer agent. Tubulin inhibitor 34 can inhibit tubulin polymerization and induce G2/M arrest and apoptosis. Tubulin inhibitor 34 exhibits significant antivascular and antitumor activity .

HY-144817

Tubulin inhibitor 27	Microtubule/Tubulin	Cancer
Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC₅₀ of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities .

HY-149375

Tubulin inhibitor 37	Microtubule/Tubulin	Cancer
Tubulin inhibitor 37 (Compound 12) is a *Tubulin* inhibitor that can effectively inhibit *Tubulin* aggregation (IC₅₀=1.3 µM). Tubulin inhibitor 37 exhibits antiproliferative activity against human tumor cell lines and has potential for studying cancer .

HY-144748

Tubulin inhibitor 17	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC₅₀ of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis .

HY-146778

Tubulin inhibitor 25	Microtubule/Tubulin	Cancer
Tubulin inhibitor 25 is a potent *tubulin* inhibitor with an IC₅₀ value of 0.98 μM. Tubulin inhibitor 25 exhibits remarkable activity against cancer cell line HT29. Tubulin inhibitor 25 displays the potent inhibition on cell migration and tube formation that contributes to the anti-angiogenesis .

HY-143250

Tubulin inhibitor 12	Microtubule/Tubulin	Cancer
Tubulin inhibitor 12 (Hit 9) is a novel *tubulin* inhibitor (IC₅₀=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity .

HY-145820

Tubulin inhibitor 14	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC₅₀ of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features .

HY-146366

Tubulin inhibitor 26	Microtubule/Tubulin	Cancer
Tubulin inhibitor 26 (compound 3c) is a potent inhibitor of *tubulin. Tubulin* inhibitor 26 is an indazole derivative compound. Tubulin inhibitor 26 shows noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 arrests tumor cell in G2/M phase and induced cell apoptosis. Tubulin inhibitor 26 suppresses tumor growth in vivo without affecting the mice body weight .

HY-147887

Tubulin inhibitor 28	Microtubule/Tubulin	Cancer
Tubulin inhibitor 28 (compound 2g) is a potent *tubulin* inhibitor with an IC₅₀ value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells .

HY-144797

Tubulin inhibitor 22	Microtubule/Tubulin	Cancer
Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of *tubulin* with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced apoptosis of MGC-803 cells through mitochondrial dysfunction .

HY-149374

Tubulin inhibitor 36	Microtubule/Tubulin	Cancer
Tubulin inhibitor 36 (Compound 10) is a novel and potent *tubulin* inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC₅₀ value of 1.5±0.1 μM. Tubulin inhibitor 36 (Compound 10) has significant anti-mitotic effect and exhibits activities against glioblastoma cells. Tubulin inhibitor 36 (Compound 10) has anti-tumor effects and can be used for glioblastoma multiforme (GBM) research .

HY-149376

Tubulin inhibitor 38	Microtubule/Tubulin	Cancer
Tubulin inhibitor 38 (compound 14) is a tetrazole-based *Tubulin* inhibitor with antiproliferative potencies. Tubulin inhibitor 38 (100 nM，24 h) mediates mitotic arrest，blocks cell cycle at G2/M phase and induces apoptosis. Tubulin inhibitor 38 exhibits high cytotoxicity with high selectivity index among HeLa，MCF7，and U87 MG cells .

HY-115970

Tubulin inhibitor 21	Microtubule/Tubulin	Cancer
Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent *tubulin* inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC₅₀=0.26 μM) with lower effect against nonmalignant cells .

HY-155073

Tubulin inhibitor 35	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC₅₀=~50 μM) and tubulin polymerization (IC₅₀=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC₅₀=0.09 μM) and RKO (IC₅₀=0.2 μM) cell lines) .

HY-161256

Tubulin inhibitor 41	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 41 (Compd D19), a promising anti-GBM (glioblastoma) lead compound and tublin inhibitor with BBB permeability, induces G2/M phase arrest, resulted in cell apoptosis and inhibits the migration of U87 cells .

HY-152088

Neuroinflammatory-IN-3	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology Cancer
Neuroinflammatory-IN-3, a *tubulin* inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization_[1] .

HY-162126

Tubulin polymerization-IN-58	Microtubule/Tubulin YAP	Cancer
Tubulin polymerization-IN-58 (Compound K18) is a tubulin polymerization inhibitor with an IC₅₀ of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research .

HY-157165

Tubulin/PARP-IN-1	Microtubule/Tubulin PARP	Cancer
Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. *Tubulin/PARP*-IN-1 inhibits PARP and tubulin with IC₅₀s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC₅₀s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-155139

Tubulin polymerization-IN-45	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-45, a tubulin-targeting agent, is a tubulin polymerization inhibitor. Tubulin polymerization-IN-45 binds to the colchicine site of tubulin. Tubulin polymerization-IN-45 induces apoptotic cell death in hepatocellular cancer (HCC) cells .

HY-155841

Tubulin polymerization-IN-46	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC₅₀ of 10 nM .

HY-16036A

ALB-109564 hydrochloride 12'-Methylthiovinblastine hydrochloride	Microtubule/Tubulin	Cancer
ALB-109564 (12'-Methylthiovinblastine) hydrochloride, a *tubulin* inhibitor, is a cytotoxic agent designed to kill cancer cells by disrupting mitosis .

HY-155359

Tubulin polymerization-IN-55	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization. Tubulin polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC₅₀ s of 8, 3, 9, 24 and 62 nM, respectively .

HY-157544

PC5-VC-PAB-MMAE	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
PC5-VC-PAB-MMAE consists the ADCs linker (PC5-VC-PAB) and potent *tubulin* inhibitor (MMAE). PC5-VC-PAB-MMAE is a agent-linker conjugate for ADC .

HY-19474

Maytansinol Ansamitocin P-0	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit *tubulin* polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research .

HY-155686

Tubulin polymerization-IN-44	Microtubule/Tubulin	Cancer
Tubulinpolymer-in-44 (compound 7w) is a strong and effective *Tubulin* inhibitor, with an IC₅₀ value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.

HY-145951

Amidate-VC-PAB-MMAF	Drug-Linker Conjugates for ADC	Cancer
Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs .

HY-148265

Antiproliferative agent-14	Microtubule/Tubulin	Cancer
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC₅₀ of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle .

HY-155249

KGP591	Microtubule/Tubulin	Cancer
KGP591 is a *tubulin* polymerization inhibitor (IC₅₀ 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA) .

HY-151397

Tubulin polymerization-IN-36	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-36 is a *tubulin* polymerization inhibitor (IC₅₀: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas .

HY-151398

Tubulin polymerization-IN-37	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-37 is a *tubulin* polymerization inhibitor (IC₅₀: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas .

Cat. No.	Product Name	Type

HY-100374G

Val-Cit-PAB-MMAE (GMP)	Fluorescent Dye
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-15582G

Auristatin E (GMP)

Fluorescent Dye

Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-15162G

Monomethyl auristatin E (GMP) MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Fluorescent Dye
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-78738G

MC-Val-Cit-PAB (GMP)	Fluorescent Dye
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-78931G

Boc-Dap-NE (GMP)	Fluorescent Dye
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-15579G

MMAF (GMP) Monomethylauristatin F (GMP)	Fluorescent Dye
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-15579BG

MMAF sodium (GMP) Monomethylauristatin F sodium (GMP)	Fluorescent Dye
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Fluorescent Dye
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

Cat. No.	Product Name	Type

HY-100374G

Val-Cit-PAB-MMAE (GMP)	Biochemical Assay Reagents
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-15582G

Auristatin E (GMP)

Biochemical Assay Reagents

Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-15162G

Monomethyl auristatin E (GMP) MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Biochemical Assay Reagents
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-78738G

MC-Val-Cit-PAB (GMP)	Biochemical Assay Reagents
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-78931G

Boc-Dap-NE (GMP)	Biochemical Assay Reagents
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-15579G

MMAF (GMP) Monomethylauristatin F (GMP)	Biochemical Assay Reagents
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-15579BG

MMAF sodium (GMP) Monomethylauristatin F sodium (GMP)	Biochemical Assay Reagents
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Biochemical Assay Reagents
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19474

Maytansinol Ansamitocin P-0	Alkaloids Microorganisms Other Alkaloids Source classification Disease Research Fields Cancer	Microtubule/Tubulin ADC Cytotoxin Apoptosis
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit *tubulin* polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research .

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Structural Classification Natural Products Classification of Application Fields Source classification Marine natural products Other marine organisms Disease Research Fields Cancer	Microtubule/Tubulin ADC Cytotoxin
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits *tubulin* polymerization.

HY-N0282

Demecolcine 3 Publications Verification	Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Plants Inflammation/Immunology Disease Research Fields	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of *tubulin* polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-13503

Epothilone A Epo A	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Epothilone A is a competitive inhibitor of the binding of [ ³H] paclitaxel to *tubulin* polymers, with a K_i of 0.6-1.4 μM.

HY-N10536

Halichondrin B	Structural Classification Natural Products Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	Others
Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC₅₀ for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity .

HY-N0687

Vindoline	Apocynaceae Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer Catharanthus roseus (L.) G. Don	Microtubule/Tubulin
Vindoline, a vinca alkaloid extracted from the leaves of Catharanthus roseus, weakly inhibits tubulin self-assembly .

HY-N2415

Podophyllotoxone	Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the *tubulin* polymerization .

HY-N9842

Violanone	Infection Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones	Microtubule/Tubulin
Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti .

HY-N3950

Glochidiol	Triterpenes Structural Classification Phyllanthaceae Glochidion eriocarpum Champ. ex Benth. Terpenoids Source classification Plants	Microtubule/Tubulin
Glochidiol is an orally active tubulin polymerization inhibitor with an IC₅₀ of 2.76 μM. Glochidiol shows anti-cancer activity .

HY-77574

7-xylosyltaxol 7-Xylosylpaclitaxel; Taxol-7-xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-N6793

Phomopsin A	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	Microtubule/Tubulin
Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to *tubulin* .

HY-N8287

Oxaline	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Microtubule/Tubulin
Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase .

HY-N8745

α-Peltatin	Structural Classification Source classification Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae	Others
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-129071

Vindesine sulfate	Apocynaceae Structural Classification Piperidine Alkaloids Pyrrole Alkaloids Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin
Vindesine sulfate is a potent *tubulin* inhibitor with an K_i of 0.110 µM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo .

HY-N10558

PM050489	Structural Classification Natural Products Animals Source classification	Microtubule/Tubulin
PM050489 is an effective polyketone inhibitor of *Microtubule/Tubulin* that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC₅₀ value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research .

HY-127166

Colchiceine O10-Demethylcolchicine	Colchicaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Colchicum autumnale L.	Microtubule/Tubulin
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a *tubulin* inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-16569

Colchicine 25+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent *tubulin* inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N1243

Tubulysin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits *tubulin* polymerization and leads to cell cycle arrest and apoptosis .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

Cat. No.	Product Name	Chemical Structure

HY-15162A

MMAE-d8

5+ Cited Publications

MMAE-d₈ is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.

HY-116852S

Thiocolchicine-d3

Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-115364S

Parbendazole-d3
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function[1][2][3][4].

HY-15575S

VcMMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

Cat. No.	Product Name		Classification

HY-136314

DBCO-PEG4-VC-PAB-MMAE		DBCO
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-126690

DBCO-(PEG2-VC-PAB-MMAE)2		DBCO
DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate . DBCO-(PEG2-VC-PAB-MMAE)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-148057

TCO-PEG4-VC-PAB-MMAE		TCO ADC Synthesis
TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162) . TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-130990

DBCO-PEG4-Val-Cit-PAB-MMAF		DBCO
DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-133492

DBCO-PEG4-MMAF		DBCO
DBCO-PEG4-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4. DBCO-PEG4-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W190943

Azido-PEG4-Val-Cit-PAB-MMAE		Azide
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-153739

N3-PEG3-VC-PAB-MMAF		Azide
N3-PEG3-VC-PAB-MMAF (Comp T-88-5) is a drug-linker conjugate containing the ADC linker N3-PEG3-VC-PAB and the tubulin inhibitor MMAF . N3-PEG3-VC-PAB-MMAF is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-100874

N3-PEG3-vc-PAB-MMAE 2 Publications Verification		Azide
N3-PEG3-vc-PAB-MMAE is a synthesized agent-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity. N3-PEG3-vc-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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